Alendronate

by Cathy Parkes April 16, 2021

Alendronate is a bisphosphonate used to treat osteoporosis. Key side effect is esophagitis. HINT: "Alen drones on and on about his esophagitis."

What is alendronate?

Alendronate is a bisphosphonate used to prevent and treat bone loss (osteoporosis) in adults.

What is osteoporosis?

Osteoporosis is a condition that causes bones to become weak and brittle. Bone is living tissue that is constantly being broken down and replaced. Osteoporosis occurs when the creation of new bone cannot keep up with the loss of old bone. 

How does alendronate work?

Alendronate works by inhibiting osteoclasts, which are responsible for breaking down and reabsorbing bone. It strengthens and thickens bones by slowing down bone loss and allowing bone building cells (osteoblasts) to work more effectively, improving bone mass.

Key side effect of alendronate

The key side effect of alendronate is esophagitis. Esophagitis is inflammation that damages the lining of the esophagus, the muscular tube that delivers food from your mouth to your stomach. 

Cool Chicken Alan drones on and on about his esophagitis. 

Key patient teaching for alendronate

Alendronate should be taken on an empty stomach in the morning with a glass of water. Sit upright (or ambulate) for 30 minutes after taking medication to prevent esophageal ulceration.



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