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Maternal Serum Alpha-fetoprotein (MSAFP)

by Cathy Parkes December 27, 2021 Updated: December 29, 2021

Maternal Serum Alpha-fetoprotein (MSAFP) is a test for genetic abnormalities performed between 15 and 20 weeks gestation.

Maternal Serum Alpha-fetoprotein (MSAFP) is a test for genetic abnormalities performed between 15 and 20 weeks gestation.

Increased MSAFP is suggestive of neural tube defects.

Decreased MSAFP is suggestive of Down syndrome. Abnormal results should be followed by an amniocentesis to confirm.

Cathy Parkes
Cathy Parkes


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